We have shared a review and a free pdf download link (Google Drive) of Fetal and Neonatal Physiology 5th Edition PDF.
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this 2-volume resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice.
The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition was published, there have been thousands of publications on various aspects of the development of health and disease; Fetal and Neonatal Physiology synthesize this knowledge into definitive guidance for today’s busy practitioner.
Features of Fetal and Neonatal Physiology 5th Edition.
- Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants.
- Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology.
- Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more.
Table of Contents.
Section I – Genetics and Embryology.
- Basic Genetic Principles.
- Prenatal Diagnosis.
- Basic Embryology.
- Regulation of Embryogenesis.
- The Extracellular Matrix in Development.
- Stem Cell Biology.
- Apoptotic Cell Death.
Section II – Placenta and Intrauterine Environment.
- Placental Development.
- Regulation of the Placental Circulation.
- Mechanisms of Transfer Across the Human Placenta.
- Endocrine and Paracrine Function of the Human Placenta.
- Fetal and Maternal Responses to Intrauterine Infection.
- Fetal Origins of Adult Disease: A Classic Hypothesis with New Relevance.
- Physiologic Effects of Multiple Pregnancy on Mother and Fetus.
- Placental function in intrauterine growth restriction.
Section III – Developmental Pharmacology and Pharmacokinetics.
- Basic Pharmacologic Principles.
- Principles of Pharmacokinetics.
- Physicochemical and Structural Properties Regulating Placental Drug Transfer.
- Drug Distribution in Fetal Life.
- Drug Transfer During Breastfeeding.
Section IV – Intrauterine and Postnatal Growth.
- Circulatory and Metabolic Changes Accompanying Fetal Growth Restriction.
- Endocrine Factors Affecting Neonatal Growth.
- Human Milk Composition and Function in the Infant.
- Physiology of Lactation.
Section V – Perinatal Iron, Mineral, and Vitamin Metabolism.
- Fetal and Neonatal Iron Metabolism.
- Neonatal Calcium, Phosphorus, and Magnesium Homeostasis.
- Zinc in the Fetus and Neonate.
- Vitamin A Metabolism in the Fetus and Neonate.
- Vitamin E Metabolism in the Fetus and Newborn Infant.
- Vitamin K Metabolism in the Fetus and Neonate.
Section VI – Lipid Metabolism.
- Maternal-Fetal Transfer of Lipid Metabolites.
- Brown Adipose Tissue: Development and Function.
- Lipids as an Energy Source for the Premature and Full-Term Neonate.
- Ketone Body Production and Metabolism in the Fetus and Neonate.
- Long-Chain Fatty Acids in the Developing Retina and Brain.
Section VII – Carbohydrate Metabolism.
- Metabolism of Glucose and Methods of Investigation in the Fetus and Newborn.
- Carbohydrate Metabolism During Pregnancy.
- Oxygen Consumption and General Carbohydrate Metabolism of the Fetus.
- Role of Glucoregulatory Hormones in Hepatic Glucose Metabolism During the Perinatal Period.
- Cell Glucose Transport and Glucose Handling During Fetal and Neonatal Development.
Section VIII – Protein Metabolism.
- General Concepts of Protein Metabolism.
- Fetal Requirements and Placental Transfer of Nitrogenous Compounds.
Section IX – Thermoregulation.
- Temperature Control in Newborn Infants.
- Responses of the Fetus and Neonate to Hypothermia.
Section X – Skin.
- Structure and Development of Skin and Cutaneous Appendages.
- Physiologic Development of the Skin.
Section XI – Fetal and Neonatal Cardiovascular Physiology.
- Cardiovascular Development.
- Developmental Electrophysiology in the Fetus and Neonate.
- Developmental Biology of the Pulmonary Vasculature.
- Development of the Gastrointestinal Circulation in the Fetus and Newborn.
- Physiology of Congenital Heart Disease in the Neonate.
- Neural Regulation of Blood Pressure During Fetal and Newborn Life.
- Developmental Effects on Fetal Circulation.
- Mechanisms Regulating Closure of the Ductus Arteriosus.
- Umbilical Circulation.
- Fetal and Placental Circulation During Labor.
- Physiology of Resuscitation.
Section XII – The Lung.
- Normal and Abnormal Structural Development of the Lung.
- Regulation of Alveolarization.
- Physiologic Mechanisms of Normal and Altered Lung Growth Before and After Birth.
- Molecular Mechanisms of Lung Development and Lung Branching Morphogenesis.
- Regulation of Liquid Secretion and Absorption by the Fetal and Neonatal Lung.
- Upper Airway Structure: Function, Regulation, and Development.
- Regulation of Lower Airway Function.
- Functional Development of Respiratory Muscles.
- Mechanics of Breathing.
- Pulmonary Gas Exchange in the Developing Lung.
- Oxygen Transport and Delivery.
- Control of Breathing in Fetal Life and Onset and Control of Breathing in the Neonate.
- Basic Mechanisms of Oxygen Sensing and Response to Hypoxia.
- Evaluation of Pulmonary Function in the Neonate.
- Mechanisms of Neonatal Lung Injury.
- Impaired Lung Growth After Injury in Premature Lung.
- Antenatal Factors That Influence Postnatal Lung Development and Injury.
- Regulation of Pulmonary Circulation.
Section XIII – Surfactant.
- Historical Perspective.
- Composition of Pulmonary Surfactant Lipids and Proteins.
- Structure And Development of Alveolar Epithelial Cells.
- Regulation of Surfactant-Associated Phospholipid Synthesis and Secretion.
- Hormonal Therapy for Prevention of Respiratory Distress Syndrome.
- Surfactant Treatment.
- Genetics and Physiology of Surfactant Protein Deficiencies.
Section XIV – Physiology of Gastrointestinal Tract in the Fetus and Neonate.
- Trophic Factors and Regulation of Gastrointestinal Tract and Liver Development.
- Organogenesis of the Gastrointestinal Tract.
- Development of the Enteric Nervous System.
- Development of Gastric Secretory Function.
- Development of Gastrointestinal Motility.
- Development of the Exocrine Pancreas.
- Digestive-Absorption Functions in Fetuses, Infants, and Children.
- Development of the Intestinal Microbiome.
Section XV – Liver and Bilirubin Metabolism.
- Organogenesis and Histologic Development of the Liver.
- Bile Acid Metabolism During Development.
- Neonatal Bilirubin Metabolism.
- Hereditary Contribution to Neonatal Hyperbilirubinemia.
- Mechanisms of Action of Phototherapy for Neonatal Hyperbilirubinemia.
Section XVI – The Kidney.
- Embryogenesis and Anatomic Development of the Kidney.
- Functional Development of the Kidney in Utero.
- Development and Regulation of Renal Blood flow in the Neonate.
- Development of the Renin-Angiotensin System.
- Postnatal Development of Glomerular Filtration Rate in Neonates.
- Renal Transport of Sodium During Early Development.
- Potassium Homeostasis in the Fetus and Neonate.
- Role of the Kidney in Calcium and Phosphorus Homeostasis.
- Transport of Amino Acids in the Fetus and Neonate.
- Developmental Aspects of Organic Acid Transport.
- Concentration and Dilution of the Urine.
- Development of Acidification Mechanisms in the Fetus and Neonate.
- Response to Nephron Loss in Early Development.
Section XVII – Fluid and Electrolyte Metabolism.
- Fluid Distribution in the Fetus and Neonate
- Regulation of Acid-Base Balance in the Fetus and Neonate.
Section XVIII – Developmental Hematopoiesis.
- Developmental Biology of Stem Cells: From the Embryo to the Adult.
- Developmental Granulocytopoiesis.
- Developmental Erythropoiesis.
- Developmental Megakaryocytopoiesis.
Section XIX – Hemostasis.
- Developmental Hemostasis.
- Platelet–Vessel Wall Interactions.
Section XX – Developmental Immunobiology.
- Host Defense Mechanisms Against Bacteria.
- Host-Fungi Interactions Relevant to the Newborn Infant.
- Host Defense Mechanisms Against Viruses.
- T-Cell Development.
- B-Cell Development.
- Mononuclear Phagocyte System.
- Normal and Abnormal Neutrophil Physiology in the Newborn.
- The Complement System of the Fetus and Newborn.
- Cytokines and Inflammatory Response in the Fetus and Neonate.
- Immunology of Human Milk and Host Immunity.
- Neonatal Pulmonary Host Defense.
Section XXI – Neurology.
- Development of the Nervous System.
- Development of the Blood-Brain Barrier.
- Trophic Factor and Nutritional and Hormonal Regulation of Brain Development.
- Intraventricular Hemorrhage in the Neonate.
- Cerebellar Development – an Impact of Preterm Birth and Co-Morbidities.
- Electroencephalography in the Premature and Full-Term Infant.
- Developmental Aspects of Pain.
Section XXII – Special Sensory Systems in the Fetus and Neonate.
- Early Development of the Human Auditory System
- Development of Taste and Smell in the Neonate
Section XXIII – Orthopedics.
- The Growth Plate: Embryologic Origin, Structure, and Function.
- Ontogenesis of Striated Muscle.
Section XXIV – Endocrine Function.
- Hypothalamus: Neuroendometabolic Center.
- Growth Factor Regulation of Fetal Growth.
- Growth Hormone in the Fetus and Newborn.
- Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in the Fetus and Newborn.
- Development of the Corticotropin-Releasing Hormone–Corticotropin System in the Mammalian Fetus.
- Fetal and Neonatal Adrenocortical Physiology.
- Fetal and Neonatal Thyroid Physiology.
Section XXV – Ovary and Testis.
- Genetics of Sex Determination and Differentiation.
- Differentiation of the Ovary.
- Testicular Development and Descent.
Section XXVI – Pathophysiology of Neonatal Diseases.
- Pathophysiology of Neonatal sepsis.
- Pathophysiology of Hypoglycemia in the Neonate.
- Pathophysiology of Cardiomyopathies.
- Pathophysiology of Persistent pulmonary hypertension of the newborn.
- Pathophysiology of Shock in the Fetus and Neonate.
- Pathophysiology of Apnea of Prematurity.
- Pathophysiology of Respiratory Distress Syndrome.
- Pathophysiology of Meconium Aspiration Syndrome.
- Pathophysiology of Bronchopulmonary Dysplasia.
- Pathophysiology of Ventilator Dependent Infants.
- Pathophysiology of Gastroesophageal Reflux.
- Pathophysiology of Neonatal Necrotizing Enterocolitis.
- Pathophysiology of Kernicterus.
- Pathophysiology of neonatal acute kidney injury.
- Pathophysiology of Edema.
- Pathophysiology of Retinopathy of Prematurity.
- Pathophysiology of Hypoxic-ischemic Brain Injury.
- Pathophysiology of Neonatal White Matter Injury.
- Pathophysiology of Meningitis.
- Pathophysiology of Neural Tube Defects.
- Pathophysiology of Preeclampsia.
- Pathophysiology of Preterm Birth.
- Pathophysiology of Chorioamnionitis.
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