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Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at the disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood.
Microbleeds have emerged as a critical imaging marker of small vessel disease, which is found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration.
Features of Cerebral Microbleeds: Pathophysiology to Clinical Practice.
- Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field.
- This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment.
- Draws together the available research on microbleeds into one accessible volume.
- Easy access to all relevant research with authoritative information and discussion.
- Systematically covers all aspects from pathology to clinical practice.
Table of Contents
Part I. Historical Aspects, Detection and Interpretation:
- Historical overview: microaneurysms, cerebral microbleeds, and intracerebral hemorrhage.
- Detection of microbleeds – physical principles, technical aspects, and new developments.
- Susceptibility-weighted imaging.
- Defining and mapping cerebral microbleeds.
- Microbleed mimics.
Part II. Mechanisms Underlying Microbleeds.
- Histopathology of cerebral microbleeds.
- Risk factors for cerebral microbleeds.
- Relationship of cerebral microbleeds to other imaging findings.
Part III. Microbleeds in Relation to Specific Populations, Diseases, and Neurological Symptoms:
- Microbleeds in healthy populations.
- Microbleeds in relation to cerebrovascular disease.
- Microbleeds in relation to hypertensive arteriopathy.
- Microbleeds in relation to cerebral amyloid angiopathy.
- Cerebral microbleeds and Alzheimer’s disease.
- Cerebral microbleeds in relation to brain trauma.
- Cerebral microbleeds in CADASIL.
- Miscellaneous conditions associated with cerebral microbleeds.
- Cerebral microbleeds and cognitive impairment.
- Other clinical manifestations of cerebral microbleeds.
- Cerebral microbleeds and antithrombotic treatment.
- Cerebral microbleeds and thrombolysis.
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