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Human blood performs many important functions including defense against disease and transport of biomolecules, but perhaps the most important is to carry oxygen – the fundamental biochemical fuel – and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centered around blood transfusions.
However scientists are developing chemicals (oxygen therapeutics, or “blood substitutes”) that have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired.
Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development.
Features of Chemistry and Biochemistry of Oxygen Therapeutics
- The first part of the book deals with the chemistry, biochemistry, physiology, and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion injury.
- The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of hemorrhages in “non-surgical” patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in β thalassemia and sickle cell disease.
- Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, hematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists, and blood substitutes researchers.
Table of Contents.
Part I : Oxygen: Chemistry, Biochemistry, Physiology, And Toxicity.
- Hemoglobin Reactivity And Regulation
- The Major Physiological Control Mechanisms Of Blood Flow And Oxygen Delivery
- The Main Players: Hemoglobin And Myoglobin; Nitric Oxide And Oxygen
- The Role Of Reactive Oxygen And Nitrogen Species In Ischemia/Reperfusion Injury
Part II: Medical Needs For Oxygen Supply.
- Acute Traumatic Hemorrhage And Anemia.
- Diagnosis And Treatment Of Haemorrhages In ‘Nonsurgical’ Patients.
- Management Of Perioperative Bleeding.
- Oxygenation In The Preterm Neonate.
- Normobaric And Hyperbaric Oxygen Therapy For Ischemic Stroke And Other Neurological Conditions.
- Transfusion Therapy In Β Thalassemia And Sickle Cell Disease.
Part III: “Old” And New Strategies For Oxygen Supply.
- Transfusion: Political, Administrative And Logistic Issues
- Conscientious Objection In-Patient Blood Management
- Red‐Cell Transfusion In Clinical Practice.
- Causes And Consequences Of Red Cell Incompatibility.
- Biochemistry Of Storage Of Red Blood Cells.
- Proteomic Investigations Of Stored Red Blood Cells.
- Red Blood Cells From Stem Cells.
- The Universal Red Blood Cell.
- Allosteric Effectors Of Hemoglobin: Past, Present, And Future.
- Hemoglobin‐Based Oxygen Carriers: History, Limits, Brief Summary Of The State Of The Art, Including Clinical Trials.
- Oxygen Delivery By Natural And Artificial Oxygen Carriers.
- Crosslinked And Polymerized Hemoglobins As Potential Blood Substitutes.
- Engineering The Molecular Shape Of Peg‐Hemoglobin Adducts For Supraperfusion.
- Hb Octamers By Introduction Of Surface Cysteines.
- Hemoglobin Vesicles As A Cellular‐Type Hemoglobin‐Based Oxygen Carrier.
- Animal Models And Oxidative Biomarkers To Evaluate Preclinical Safety Of Extracellular Hemoglobins.
- Academia-Industry Collaboration In Blood Substitute Development: Issues, Case Histories, And A Proposal.
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